NEW Modified Polyethersulfone Hollow Fiber Filter Modules
Single-Use Ultrafiltration Filter Modules for faster Tangential Flow Filtration
Modified Polyethersulfone (mPES) is an advanced hydrophilic membrane filtration chemistry that provides higher flux
rates for faster processing times, excellent selectivity for separation applications, and low protein binding for
higher product yields than other membrane chemistries. Spectrum's new modified Polyethersulfone hollow fiber filters
provide all the benefits of modified PES chemistry in fully encapsulated filter modules that are priced for Single-Use.
With Spectrum's Single-Use mPES hollow fiber filters, total development and production costs are decreased through
the combination of faster processing times, decreased labor costs associated with filter cleaning for re-use and
a reduction in the use of costly WFI water. Low protein binding increases the product yield of each processing run.
Single-Use eliminates the need for costly stainless steel systems and increases manufacturing flexibility.
Spectrum's mPES filters are available in 3 kD, 5 kD, 10 kD, 30 kD, 50 kD, 70 kD, 100 kD, 300 kD, 500 kD MWCOs and 0.2 µm pore sizes. All are available with 0.5mm fiber ID. 3kD, 30kD, 50kD, 100kD, 300kD and 500kD filters are also available with 1.0mm fiber ID.
mPES Hollow Fiber Filters for Tangential Filtration have significant advantages over other filter configurations,
like cassettes and dead-end filters. Tangential Flow Filtration (TFF) involves the recirculation of the retentate
across the surface of the Hollow Fiber membrane. This gentle cross flow feed acts to minimize membrane fouling,
maintain a high filtration rate and provide higher product recovery. The void free structure of mPES hollow fiber, shown in the SEMs, increases the membrane's tensile strength resulting in increased durability during processing. Hollow Fiber Filters are directly scalable
from R&D volumes to full production. Optimum processing parameters determine for small-scale volumes can be used
for larger volumes by maintaining the effective length of the filter (EL) and increasing membrane surface area.
Cross Section of a 30 kD 0.5mm ID mPES Hollow Fiber @ 100X Magnification
Cross Section of a 30 kD 0.5mm ID mPES Hollow Fiber @ 750X Magnification
0.5 mm ID mPES filters are available in 7 filter module configurations with 3 effective lengths and 10 MWCOs; 1.0 mm ID mPES filters are available in 7 filter module configurations with 3 effective lengths and 6 MWCOs:
Fiber ID
MWCOs
Modified Polyethersulfone (mPES)
0.5mm
3kD,5kD,10kD,30kD,50kD,70kD,100kD, 300kD, 500kD and 0.2µm
Designed for tangential flow filtration of small volumes ranging from 1 mL to 100 mL, single-use MicroKros® hollow fiber filters
are the first efficient and practical tangential flow filtration device for characterizing a process for scale-up or filtration of
small volumes in a laboratory setting. MicroKros® are available with FLL x FLL connections and 1 length.
Designed for tangential flow filtration of small volumes ranging from 100 mL to 3 L, MidiKros® hollow fiber filters are practical
devices suitable for starting batch volumes in an R&D setting. MidiKros® filters have FLL x FLL connections and
come in 3 effective lengths. Surface areas range from 115 cm2 to 370 cm2.
Designed for tangential flow filtration of small volumes ranging from 100 mL to 3 L, MidiKros® TC hollow fiber filters are
practical devices suitable for starting batch volumes in an R&D setting. MidiKros® TC filters have 1/2" TC x FLL
connections and come in 3 effective lengths. Surface areas range from 115 cm2 to 370 cm2.
Designed for tangential flow filtration of volumes ranging from 3 L to 15 L, MiniKros® Sampler hollow fiber filters
are the ideal devices for filtering small batch volumes. MiniKros® Sampler filters have 3/4" TC x 3/4" TC connections
and come in 3 effective lengths. Surface areas range from 790 cm2 to 2600 cm2.
Designed for tangential flow filtration of volumes ranging from 5 L to 50 L, MiniKros® hollow fiber filters are suited
for pilot scale applications. MiniKros® filters have 1-1/2" TC x 3/4" TC connections and come in 3 effective lengths.
Surface areas range from 2600 cm2 to 8500 cm2.
Designed for tangential flow filtration of volumes ranging from 10 L to 100 L, KrosFlo® hollow fiber filters are
suited for production scale applications. KrosFlo® filters have 3" TC x 1-1/2" TC connections and come in 3
effective lengths Surface areas range from 1.25 m2 to 4.1 m2.
Designed for tangential flow filtration of volumes ranging from 100 L to 1000+ L, KrosFlo® Max hollow fiber
filter are suited for production scale applications. KrosFlo® Max filters have 2" TC x 6" TC Connections
Call Customer Service for sizes and part numbers at 800-634-3300 (toll-free US and Canada)
or 310-885-4600 (world-wide) or email us: customerservice@spectrumlabs.com.
Advantages of Spectrum Single Use Filters
Saves Money & Time
No Cross-Contamination
Less Down-Time
Low Shear
Directly Scalable for Production
Easy Retrofit for other Hollow Fiber Filters
Applications:
Cell Concentration, Clarification and Diafiltration
Lysate Clarification
VLP and Virus Concentration and Diafiltration
VLP and Virus Clarification
Protein Purification, Concentration and Diafiltration
Nucleic Acid Diafiltration and Concentration
NanoParticle and Latex Particle Diafiltration and Fractionation
In situ Conjugation and Fractionation
Bacteria Concentration and Diafiltration
Liposome, siRNA Concentration and Diafiltration
Inclusion body Clarification and Concentration
Bioreactor cell Perfusion and Media Exchange
Filtration Resources:
RELATED PRODUCT:
KrosFlo® Research IIi System
for volumes 1 mL to 10 L Learn More >
MiniKros® Pilot System
for volumes 10 L to 1000 L Learn More >
