change your region: Europe France Germany Japan China  
Edition: U.S.

Spectrum Labs, the leader in filtration and laboratory dialysis.
site map | search> 
 
Click to register to shop on-lineClick for information on how to contact us.Click for information about who we are.Click for print formatted product literature.Click to fill out our customer satisfaction survey.Click for information on which trade shows we will be attending.
New Products
Filtration Products
Process Filtration
Process Filtration Systems
Laboratory Filtration
Disposable Bag Products
Perfusion Assemblies and Systems at Spectrum Labs
Laboratory Dialysis Products
Labware Products
Cell Culture Products
Chromatography Products
Operating Room Disposables
OEM Products

We are ISO 9001:2008 certified
Newsletter Sign-up

NEW Modified Polyethersulfone
Hollow Fiber Filter Modules


Single-Use Ultrafiltration Filter Modules for faster Tangential Flow Filtration


Down to list of module typesdown to introductory video
Modified Polyethersulfone (mPES) is an advanced hydrophilic membrane filtration chemistry that provides higher flux rates for faster processing times, excellent selectivity for separation applications, and low protein binding for higher product yields than other membrane chemistries. Spectrum's new modified Polyethersulfone hollow fiber filters provide all the benefits of modified PES chemistry in fully encapsulated filter modules that are priced for Single-Use. With Spectrum's Single-Use mPES hollow fiber filters, total development and production costs are decreased through the combination of faster processing times, decreased labor costs associated with filter cleaning for re-use and a reduction in the use of costly WFI water. Low protein binding increases the product yield of each processing run. Single-Use eliminates the need for costly stainless steel systems and increases manufacturing flexibility. Spectrum's mPES filters are available in 3 kD, 5 kD, 10 kD, 30 kD, 50 kD, 70 kD, 100 kD, 300 kD, 500 kD MWCOs and 0.2 µm pore sizes. All are available with 0.5mm fiber ID. 3kD, 30kD, 50kD, 100kD, 300kD and 500kD are also available with 1.0mm fiber ID.

mPES Hollow Fiber Filters for Tangential Filtration have significant advantages over other filter configurations, like cassettes and dead-end filters. Tangential Flow Filtration (TFF) involves the recirculation of the retentate across the surface of the Hollow Fiber membrane. This gentle cross flow feed acts to minimize membrane fouling, maintain a high filtration rate and provide higher product recovery. Hollow Fiber Filters are directly scalable from R&D volumes to full production. Optimum processing parameters determine for small-scale volumes can be used for larger volumes by maintaining the effective length of the filter (EL) and increasing membrane surface area.

Cross Section of a 30 kD 0.5mm ID mPES Hollow Fiber @ 100X Magnification
Cross Section of a 30 kD 0.5mm ID mPES Hollow Fiber @ 750X Magnification

0.5 mm ID mPES filters are available in 7 filter module configurations with 3 effective lengths and 10 MWCOs; 1.0 mm ID mPES filters are available in 7 filter module configurations with 3 effective lengths and 6 MWCOs:


Fiber IDMWCOs
Modified Polyethersulfone (mPES)0.5mm3kD,5kD,10kD,30kD,50kD,70kD,100kD, 300kD, 500kD and 0.2µm
1.0mm3kD, 30kD, 50kD, 100kD, 300kD and 500kD

mPES Filter Module Types

MicroKros® Filter Modules


Designed for tangential flow filtration of small volumes ranging from 1 mL to 100 mL, single-use MicroKros® hollow fiber filters are the first efficient and practical tangential flow filtration device for characterizing a process for scale-up or filtration of small volumes in a laboratory setting. MicroKros® are available with MLL x FLL connections and 1 Effective Length.
 

MidiKros® Filter Modules


Designed for tangential flow filtration of small volumes ranging from 100 mL to 3 L, MidiKros® hollow fiber filters are practical devices suitable for starting batch volumes in an R&D setting. MidiKros® filters have FLL x FLL connections and come in 3 effective lengths. Surface areas range from 115 cm2 to 370 cm2.
 

MidiKros® TC Filter Modules


Designed for tangential flow filtration of small volumes ranging from 100 mL to 3 L, MidiKros® TC hollow fiber filters are practical devices suitable for starting batch volumes in an R&D setting. MidiKros® TC filters have 1/2" TC x FLL connections and come in 3 effective lengths. Surface areas range from 115 cm2 to 370 cm2.
 

MiniKros® Sampler Filter Modules


Designed for tangential flow filtration of volumes ranging from 3 L to 15 L, MiniKros® Sampler hollow fiber filters are the ideal devices for filtering small batch volumes. MiniKros® Sampler filters have 3/4" TC x 3/4" TC connections and come in 3 effective lengths. Surface areas range from 790 cm2 to 2600 cm2.
 

MiniKros® Filter Modules


Designed for tangential flow filtration of volumes ranging from 5 L to 50 L, MiniKros® hollow fiber filters are suited for pilot scale applications. MiniKros® filters have 1-1/2" TC x 3/4" TC connections and come in 3 effective lengths. Surface areas range from 2600 cm2 to 8500 cm2.
 

KrosFlo® Filter Modules


Designed for tangential flow filtration of volumes ranging from 10 L to 100 L, KrosFlo® hollow fiber filters are suited for production scale applications. KrosFlo® filters have 3" TC x 1-1/2" TC connections and come in 3 effective lengths. Surface areas range from 1.25 m2 to 4.1 m2.
 

KrosFlo® Max Filter Modules


Designed for tangential flow filtration of volumes ranging from 100 L to 1000+ L, KrosFlo® Max hollow fiber filter are suited for production scale applications. KrosFlo® Max filters have 6" TC x 2" TC and come in four effective lengths. Surface areas range from 4.3m2 to 11.35m2.
 

Advantages of Disposability

  • Easier FDA Validation
  • Saves Money & Time
  • No Cross-Contamination
  • Less Down-Time
  • Low Shear
  • Directly Scalable for Production
  • Easy Retrofit for other HF Modules

Applications:

  • Cell Concentration, Clarification and Diafiltration
  • Lysate Clarification
  • VLP and Virus Concentration and Diafiltration
  • VLP and Virus Clarification
  • Protein Purification, Concentration and Diafiltration
  • Nucleic Acid Diafiltration and Concentration
  • NanoParticle and Latex Particle Diafiltration and Fractionation
  • In situ Conjugation and Fractionation
  • Bacteria Concentration and Diafiltration
  • Liposome, siRNA Concentration and Diafiltration
  • Inclusion body Clarification and Concentration
  • Bioreactor cell Perfusion and Media Exchange

Filtration Resources:

Product Brochure
Product Literature
Fundamentals of Filtration
Spectrum's Competitive Edge
Our HF Membranes vs. Others
Scalability of Process Modules
Application Guide
HF Filter Modules Standard Product Number Key
Chemical Compatibility Chart
Pore Size Chart

Ask any filtration question at filterchat.com and get an immediate response.

RELATED PRODUCT:

KrosFlo® Research IIi System
for volumes 1 mL to 10 L
Learn More >

MiniKros® Pilot System
for volumes 10 L to 1000 L
Learn More >

Back Pressure Valve
Learn More >

KrosFlo® LDF-37 System
for volumes from 50 L to 750+ L
Learn More >

hi dave
copyright © 1995-2014 SPECTRUM® LABORATORIES, INC All rights reserved | Privacy Policy | Sales Terms and Conditions | Site FAQ's
 
You can order on-line using a credit card or purchase order or call us to use almost any form of payment.Click to register to shop.Click to register to shop.Click to register to shop.Click for a list of our phone numbers.