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MiniKros® Sampler Modules


Disposable Hollow Fiber Tangential Flow Modules for R & D Scale Volumes

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The MiniKros Sampler module is the ideal device for the efficient filtration of R & D scale volumes of precious samples. Tangential flow filtration is the most efficient alternative for the gentle processing of delicate samples like dissolved biological or cellular suspensions. The Spectrum MiniKros Sampler module consists of high quality hollow fiber membranes encased in a polysulfone housing with circulation inlet and outlet ports and two filtration side ports. The hollow fiber membrane geometry provides consistent filtration performance, direct scalability and high product recovery due to capillary flow dynamics. MiniKros Sampler modules can be autoclaved or are available irradiated (irr).

KrosFlo Research IIi System


Utilizes a peristaltic pump to recirculate the sample and quickly process R & D scale volumes (50 mL to 3 liters) for filtration characterization. The desired product can be purified and concentrated as retentate or clarified and purified as filtrate depending on the size of desired product and the filter pore size or MWCO.
Dimensions:
SS (cm2)Scale LengthID (mm)TL (cm)L (cm)EL (cm)
120-6152/3xFL18.818.513.912.2
165-10501xFL18.827.622.320.8

Specifications:

Housing:Polysulfone
Connections:1/4 inch hose barb inlet/outlet ports
Female Luer Lok filtrate (FLL)
Potting:Polyurethane
Process Volume:50 mL to 3 Liters
Surface Area:120 to 1050 cm2

MembraneFiber IDMWCO
Mixed Cellulose Ester (ME)0.6 mm, 1.0 mm0.2 µm, 0.1 µm
Polyethersulfone (PES)0.5 mm, 1.0 mm0.5 µm, 0.2 µm
Polysulfone (PS)0.5 mm0.05 µm, 20 nm (500 kD), 100 kD, 50 kD, 10 kD

1.0 mm100 kD

Advantages of Disposability

  • Easier FDA Validation
  • Saves Money & Time
  • No Cross-Contamination
  • Less Down-Time
  • Low Shear
  • Directly Scalable for Production
  • Easy Retrofit for other HF Modules

Applications:

  • Cell Concentration, Clarification and Diafiltration
  • Lysate Clarification
  • VLP and Virus Concentration and Diafiltration
  • VLP and Virus Clarification
  • Protein Purification, Concentration and Diafiltration
  • Nucleic Acid Diafiltration and Concentration
  • NanoParticle and Latex Particle Diafiltration and Fractionation
  • In situ Conjugation and Fractionation
  • Bacteria Concentration and Diafiltration
  • Liposome, siRNA Concentration and Diafiltration
  • Inclusion body Clarification and Concentration
  • Bioreactor cell Perfusion and Media Exchange

Filtration Resources:

Product Literature
Fundamentals of Filtration
Spectrum's Competitive Edge
Our HF Membranes vs. Others
Scalability of Process Modules
Application Guide
Chemical Compatibility Chart
Pore Size Chart


Ask any filtration question at filterchat.com and get an immediate response.
RELATED PRODUCTS:

KrosFlo Research IIi System
for 50 ml to 3 liters
Learn More >

hi dave
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