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MidiKros® Modules


Hollow Fiber Modules For Small Volume Process Separation

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Designed for tangential membrane process separations for small volumes, MidiKros disposable filters are practical devices suitable for starting batch volumes ranging from 20 mL to 2.5 L.

These modules are an ideal alternative to centrifugation for applications where pellet formation is undesirable. Flow is supplied using a peristaltic pump. MidiKros modules are hollow fiber membranes encased in a polysulfone housing. MidiKros modules are scalable and autoclavable with a membrane surface area ranging from 20 to 460 cm2. They are also available irradiated (irr).

Process fluid is pumped through the inlet port, flows tangentially across the membrane lumenal surface and exits the opposite end of the module through the outlet port. While the majority of the stream and constituents is rejected and continues down stream, a small percentage passes through the membrane into the extra-capillary space as permeate.

Dimensions:
1/4" Hose Barb (HB) inlet/outlet with Female Luer Lok (FLL) filtrate port
SA (cm2)Scale LengthID (mm)TL (cm)L (cm)EL (cm)
22-551/3xFL7.813.29.88.0
40-852/3xFL7.817.813.711.8
60-1451xFL7.825.822.220.3
Dimensions:
Female Luer Lok (FLL) inlet/outlet ports with Female Luer Lok (FLL) filtrate port
SA (cm2)Scale LengthID (mm)TL (cm)L (cm)EL (cm)
60-1451xFL7.824.522.220.3
130-2902xFL7.845.443.241.5
200-4603xFL7.868.966.765

Specifications:

Housing:Polysulfone
Connections:1/4" Hose Barb (HB) or Female Luer Lok inlet/outlet ports
(FLL) filtrate ports
Potting:Polyurethane
Starting Batch Volume:20 mL to 2.5 L
Surface Area:20 to 460 cm2

MembraneFiber IDMWCO
Mixed Cellulose Ester (ME)0.6 mm, 1.0 mm0.2 µm, 0.1 µm
Polyethersulfone (PES)0.5 mm, 1.0 mm0.5 µm, 0.2 µm
Polysulfone (PS)0.5 mm0.05 µm, 20 nm (500 kD), 100 kD, 50 kD, 10 kD

1.0 mm100 kD

Advantages of Disposability

  • Easier FDA Validation
  • Saves Money & Time
  • No Cross-Contamination
  • Less Down-Time
  • Low Shear
  • Directly Scalable for Production
  • Easy Retrofit for other HF Modules

Applications:

  • Cell Concentration, Clarification and Diafiltration
  • Lysate Clarification
  • VLP and Virus Concentration and Diafiltration
  • VLP and Virus Clarification
  • Protein Purification, Concentration and Diafiltration
  • Nucleic Acid Diafiltration and Concentration
  • NanoParticle and Latex Particle Diafiltration and Fractionation
  • In situ Conjugation and Fractionation
  • Bacteria Concentration and Diafiltration
  • Liposome, siRNA Concentration and Diafiltration
  • Inclusion body Clarification and Concentration
  • Bioreactor cell Perfusion and Media Exchange

Filtration Resources:

Product Literature
Fundamentals of Filtration
Spectrum's Competitive Edge
Our HF Membranes vs. Others
Scalability of Process Modules
Application Guide
Chemical Compatibility Chart
Pore Size Chart


Ask any filtration question at filterchat.com and get an immediate response.
RELATED PRODUCTS:

KrosFlo Research IIi System
for volumes of 10 ml to 200 ml
Learn More >

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